Recent Advancement of MMP Inhibitors
نویسندگان
چکیده
Volume 4 • Issue 2 • 1000e112 Adv Tech Biol Med ISSN: 2379-1764 ATBM, an open access journal Matrix metalloproteinase (MMPs) are a family of zinc dependent endopeptidases that play a significant role in cancer as well as in numerous other diseases [1]. It degrades the extracellular matrix (ECM) components and controlled remodeling of ECM is essential for invasion, metastasis and growth of various malignant tumors [2]. Collagen based matrix metalloproteinase (MMP) inhibitors were the first generation of MMP inhibitors. MMP inhibitors block or inactivate the functional activity of various MMPs. These enzymes have the capability to degrade all the components of connective tissue. It is well known that the expression of MMPs is elevated in many pathological conditions and many metabolic disorders.
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